summary: Recently, probiotics have attracted increased attention for their antioxidant and anti-inflammatory properties. Researchers tested the ability of probiotics to compare oxidative stress and inflammation caused by a lack of sleep. The findings concluded that probiotic supplementation could be a positive strategy to counter oxidative stress and inflammation promoted by lack of sleep.
source: Camerino University
Sleep is an essential behavior that fills nearly a third of a person’s life and is critical to physical and mental health.
Chronic sleep restriction (CSR) is generally defined as periods of habitual sleep of less than seven hours, but more than four hours per night. CSR can lead to a range of brain deficits, including impairments in attention and learning, and is associated with an increased risk of neuropsychiatric disorders and other conditions.
The new findings support that probiotic supplementation reduces the impact of inflammation and oxidative stress caused by CSR.
Epidemiological investigations have estimated that about 30% of adults and adolescents regularly suffer from inadequate sleep often due to occupational commitments and lifestyle habits.
Increasing evidence has demonstrated that CSR is associated with low-grade inflammation, as evidenced by increased inflammatory plasma cytokines and the presence of other markers of inflammation in the brain, such as activation of microglia cells.
In addition, insufficient sleep can lead to a buildup of intracellular reactive oxygen species (ROS) and/or reactive nitrogen species (RNS), leading to an imbalance between the redox and antioxidant systems in the body.
Excessive ROS and RNS can interact with carbohydrates, proteins, lipids, and DNA, thereby causing cellular damage associated with oxidative stress and increasing the risk of disease and, in extreme cases, even death.
Sleep deprivation also affects energy balance and has been associated with disturbed blood levels of peptide hormones, including ghrelin, leptin, and glucagon-like peptide 1 (GLP-1). [13,14]. Probiotics have attracted increased attention in recent years for their ability to relieve inflammation-related illnesses.
Several studies have suggested that probiotics can effectively reduce peripheral and central inflammation through multiple pathways. The underlying mechanism is associated with rebalancing altered gut flora, improved intestinal permeability, and modulation of immune function with decreased production of proinflammatory cytokines.
Moreover, probiotics can regulate the maturation and activity of microglia, and may also inhibit neuroinflammatory processes, with a positive effect in a series of diseases, such as inflammatory bowel disease, obesity, and neurodegenerative conditions.
It has also been observed that probiotics and/or bacterial metabolites can interact with the host by modulating the level of endogenous and exogenous ROS, which ultimately leads to improved redox status.
Long-term supplementation with a multi-strain probiotic formulation induced antioxidant and neuroprotective effects in a transgenic Alzheimer’s disease mouse model by activating information silencing-related enzyme pathway 1 (SIRT1).
Numerous studies have provided evidence that sleep deprivation can upset the composition of the gut microbiota. By inducing a breakdown in the intestinal epithelial barrier, sleep disruption may lead to the passage of bacteria and their end products, affecting the host and promoting immune reaction and inflammation.
Thus, the inflammation associated with sleep loss may depend, at least in part, on a change in the physiology of the gut microbiota. There is also evidence that giving probiotics can improve sleep.
Manipulating the gut microbiota by administering single- or multi-strain probiotics can improve sleep quality by decreasing the Pittsburgh Sleep Quality Index (PSQI), a common predictor of poor sleep quality.
Our multidisciplinary, multicentre team tested the hypothesis that regular oral nutritional supplementation with a multi-strain probiotic formula can reduce oxidative stress and inflammation caused by csr.
In this assay, we administered a mixture of several probiotic strains (SLAB51 formulation sold as Agimixx®) or vehicle in normal sleepy mice and in mice exposed to CSR, and evaluated the extent of oxidative damage and inflammation in the brain and systemic. level using biochemical and morphological methods.
About this insomnia research news
author: Anna Maria Elliott’s doctor
source: Camerino University
communication: Dr.. Anna Marie Elliott – Camerino University
picture: the image is in the public domain
Original search: open access.
“Probiotic supplementation relieves inflammation and oxidative stress caused by chronic sleep restriction,” by Anna Marie Elliott, et al. Nutrients
Probiotic supplementation relieves inflammation and oxidative stress caused by chronic sleep restrictions
background: Inadequate sleep is a serious public health problem in modern society. It leads to an increased risk of chronic disease, and has often been associated with cellular oxidative damage and the spread of low-grade inflammation. Probiotics have been attracting increased attention recently for their antioxidant and anti-inflammatory properties. Here, we tested the ability of probiotics to compare oxidative stress and inflammation caused by a lack of sleep.
Methods: We administered a multistrain probiotic formula (SLAB51) or water to normal sleeping rats and to rats subjected to seven days of chronic sleep restriction (CSR). We quantified oxidation of proteins, lipids, and DNA as well as levels of gut-brain axis hormones and pro- and anti-inflammatory cytokines in brain and plasma. Furthermore, we performed an assessment of microglia morphology and density in the mouse cerebral cortex.
results: We found that CSR causes oxidative stress, inflammation, and altered gut-brain axis hormones. Oral administration of SLAB51 enhanced the antioxidant capacity of the brain, limiting oxidative damage caused by lack of sleep. Moreover, it positively regulates gut-brain axis hormones and reduces CSR-induced peripheral and brain inflammation.
Conclusions: Probiotic supplementation could be a possible strategy to counteract oxidative stress and inflammation caused by a lack of sleep.